ADS032 is a dual NLRP1/NLRP3 inhibitor that rapidly and reversibly blocks inflammasome formation, suppressing IL-1beta and TNF-alpha production in human immune and epithelial cells. It reduces NLRP3-driven ASC speck formation, protects mice from lethal influenza A by dampening lung inflammation, and inhibits Nigericin-induced IL-1beta secretion (IC50 = 94.6 µM, no washout, 354 µM, washout).
Molecular Weight:
403.54
Purity:
>98% (HPLC)
CAS Number:
[2757333-37-0]
Formula:
C22H29NO4S
Target:
NOD
Application Notes:
Solubility: DMSO : 100 mg/mL (247.81 mM, Ultrasonic )
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