Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1µM NecroX(TM)-2 prevented ~50% cell death in H9C2 cells exposed to 400µM t-BuOOH for 2
Molecular Weight:
516.7
Purity:
95% (NMR, LCMS)
Formula:
C25H32N4O4S2
Application Notes:
For in vitro applications, dissolve in DMSO to 20-50mM stock solution and dilute further in cell culture media. Treat cells with 30µM to 0.1µM final concentration.Optimal conditions must be determined individually for each application.
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