Chemical Name: 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone. Alternate Names: Arabinocytidine, Cytosine beta-D-Arabinofuranoside, U-19920A, Ara-C
DNA synthesis and transcription disruptor
Molecular Weight:
243.22
Purity:
98% by HPLC NMR (Conforms)
Form:
White or off-white solid
CAS Number:
[147-94-4]
Formula:
C9H13N3O5
Application Notes:
A nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells.1,2 It Cellular enzymes convert it to its nucleotide form, Ara-CTP, which disrupts DNA and RNA synthesis when polymerases attempt to incorporate it.3,4 For the same reasons, it is also employed as an antiviral.5 It inhibits proliferation of a variety of leukemic cell lines (IC50s 16-72 nM), but is used primarily against acute myeloid leukemia (AML).6,7
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