Chemical Name: 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
PKR inhibitor
Molecular Weight:
268.30
Purity:
98% by TLC, NMR Conforms
Form:
Orange solid
CAS Number:
[608512-97-6]
Formula:
C13H8N4OS
Application Notes:
Inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM)1. Inhibits ER stress-induced neuronal damage2. Reduces brain PKR activation in vivo3. Prevents apoptosis and IL-1beta production in an acute excitotoxic and neuroinflammatory rat model4. Prevents beta-amyloid peptide-induced inflammation in primary murine mixed co-cultures5. Cell permeable.
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