Chemical Name: 3,5-bis[(4-Nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one. Alternate Names: NSC-687852
DUB inhibitor
Molecular Weight:
419.40
Purity:
>98% by HPLC
Form:
Pale yellow solid. (MP = 170-174C)
CAS Number:
[1009817-63-3]
Formula:
C22H17N3O6
Application Notes:
Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.
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