Chemical Name: 6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine
Inhibits autophagy by inhibiting USP 10 and 13
Molecular Weight:
271.27
Purity:
98% by TLC, NMR (Conforms)
Form:
Tan solid
CAS Number:
[1262888-28-7]
Formula:
C15H11F2N3
Application Notes:
A specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes1. Deranges dengue virion maturation2. Inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells3. Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency4. Cell permeable.
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