AG-1517 HCl, CAS [[153436-54-5]]

Product Overview

• Article Name: AG-1517 HCl, CAS [[153436-54-5]]
• Biozol Catalog Number: FBM-10-1377
• Supplier Catalog Number: 10-1377
• Alternative Catalog Number: FBM-10-1377-5MG, FBM-10-1377-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochloride. Alternate Names: PD153,053, SU-5271, Z-252868

Product Description

Tyrosine kinase inhibitor

Product Properties

• Molecular Weight: 360.21
• Purity: 98% by TLC, NMR (Conforms)
• Form: white or off-white solid
• CAS Number: [153436-54-5]
• Formula: C16H14BrN3O2

Application Notes

• Application Notes: An ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFRK), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation1. Inhibits the growth of a number of cancer cell lines2. An extremely useful tool for exploring EGF-mediated cellular signaling3.