BMS-303141, CAS [[943962-47-8]]

Product Overview

• Article Name: BMS-303141, CAS [[943962-47-8]]
• Biozol Catalog Number: FBM-10-1414
• Supplier Catalog Number: 10-1414
• Alternative Catalog Number: FBM-10-1414-5MG, FBM-10-1414-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1-biphenyl]-3-yl)-benzenesulfonamide. Alternate Names: ACLYi

Product Description

ATP citrate lyase (ACL) inhibitor

Product Properties

• Molecular Weight: 424.30
• Purity: 98% by TLC NMR (Conforms)
• Form: White solid
• CAS Number: [943962-47-8]
• Formula: C19H15Cl2NO4S

Application Notes

• Application Notes: Potent and selective ATP citrate lyase (ACL) inhibitor, IC50=0.13 M. Inhibits lipid biosynthesis, IC50=8 M in HepG2 cells.1,2 Reduces weight gain, lowers plasma cholesterol, triglycerides and glucose in high-fat-fed mice.2 A novel tool compound for exploring the potential of ACL inhibition as a target for metabolic disorders such as obesity and dyslipidemia.2 Impairs proliferation or induces death in androgen-depleted castration resistant prostate cancer cells.3 Reduces cell cycle progression in iBN cells.4