CZC-54252, CAS [[1191911-27-9]]

Product Overview

• Article Name: CZC-54252, CAS [[1191911-27-9]]
• Biozol Catalog Number: FBM-10-1421
• Supplier Catalog Number: 10-1421
• Alternative Catalog Number: FBM-10-1421-5MG, FBM-10-1421-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[[[5-Chloro-2-[[2-methoxy-4-(4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-phenyl]methanesulfonamide hydrochloride

Product Description

LRRK2

Product Properties

• Molecular Weight: 541.46
• Purity: 98% by TLC, NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1191911-27-9]
• Formula: C22H25ClN6O4S HCl

Application Notes

• Application Notes: Novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM1. Attenuates the neuronal damage elicited by the action of LRRK2 G2019S mutant in primary human neurons (EC50 = 1 nM)1. The G2019S mutant is a common mutation found in familial Parkinsons disease patients2. Cell permeable.