Gue1654, CAS [[397290-30-1]]

Product Overview

• Article Name: Gue1654, CAS [[397290-30-1]]
• Biozol Catalog Number: FBM-10-1425
• Supplier Catalog Number: 10-1425
• Alternative Catalog Number: FBM-10-1425-5MG, FBM-10-1425-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[7-(Methylthio)benzo[1,2-d:4,3-d]bisthiazol-2-yl]-alpha-phenylbenzeneacetamide

Product Description

OXE-R biased antagonist

Product Properties

• Molecular Weight: 447.59
• Purity: >98% by TLC, NMR (Conforms)
• Form: Off-white solid
• CAS Number: [397290-30-1]
• Formula: C23H17N3OS3

Application Notes

• Application Notes: Gue1654 is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicosanoid2. It selectively inhibits Gbetagamma but not Galphai signaling upon activation of the Galphai-betagamma heterotrimer by OXE-R.1,3 Gue1654 alleviated coronary artery ligation-induced ischemic myocardial injury in a mouse model.4