ML297, CAS [[1443246-62-5]]

Product Overview

• Article Name: ML297, CAS [[1443246-62-5]]
• Biozol Catalog Number: FBM-10-1469
• Supplier Catalog Number: 10-1469
• Alternative Catalog Number: FBM-10-1469-5MG,FBM-10-1469-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: VU0456810

Product Description

GIRK inhibitor

Product Properties

• Molecular Weight: 328.32
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [1443246-62-5]
• Formula: C17H14F2N4O

Application Notes

• Application Notes: Selective GIRK (Kir3.1/3.2) channel activator, IC50 = 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively. Has no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels.1,2 Displays antiseizure activity2 and decreases anxiety-related behavior without sedative or addictive effects3. Reduces glucose- and IBMX-stimulated GLP-1 secretion with no effect on GIP in murine L and K cells.4 Brain penetrant.