YM-155, CAS [[781661-94-7]]

Product Overview

• Article Name: YM-155, CAS [[781661-94-7]]
• Biozol Catalog Number: FBM-10-1473
• Supplier Catalog Number: 10-1473
• Alternative Catalog Number: FBM-10-1473-5MG, FBM-10-1473-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide. Alternate Names: Sepantronium bromide

Product Description

Survivin inhibitor

Product Properties

• Molecular Weight: 443.30
• Purity: >98% by TLC NMR (Conforms)
• Form: Tan to yellow solid
• CAS Number: [781661-94-7]
• Formula: C20H19BrN4O3

Application Notes

• Application Notes: A novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1 Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2 Induces DNA damage.3 Induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4