AI-3, CAS [[882288-28-0]]

Product Overview

• Article Name: AI-3, CAS [[882288-28-0]]
• Biozol Catalog Number: FBM-10-1497
• Supplier Catalog Number: 10-1497
• Alternative Catalog Number: FBM-10-1497-5MG, FBM-10-1497-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one

Product Description

ARE activator

Product Properties

• Molecular Weight: 292.81
• Purity: 98% by TLC, NMR (Conforms)
• Form: white solid MP = 71-74C
• CAS Number: [882288-28-0]
• Formula: C11H13ClO3S2

Application Notes

• Application Notes: Activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations. Disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. Activates ARE in an Nrf2 and PI 3-kinase dependent manner. Cell permeable and active in vivo.