STF-083010, CAS [[307543-71-1]]

Product Overview

• Article Name: STF-083010, CAS [[307543-71-1]]
• Biozol Catalog Number: FBM-10-1510
• Supplier Catalog Number: 10-1510
• Alternative Catalog Number: FBM-10-1510-5MG, FBM-10-1510-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide

Product Description

IRE1 ribonuclease inhibitor

Product Properties

• Molecular Weight: 317.39
• Purity: 98% by TLC, NMR (Conforms)
• Form: yellow solid
• CAS Number: [307543-71-1]
• Formula: C15H11NO3S2

Application Notes

• Application Notes: A novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress1-3. It displays significant antimyeloma activity in model human MM xenografts1. Induces apoptosis in pancreatic cancer cells and displays growth inhibition in a clonogenic growth assay in soft agar as well as in a xenograft in vivo model of pancreatic cancer4. Active in vivo.