Chemical Name: 12,13-Dihydro-13-oxopyrido[1,2-a:3,4-b]diindol-5-ium chloride
CDK4 inhibitor
Molecular Weight:
306.75
Purity:
98% by TLC, NMR (Conforms)
Form:
Dark red-brown solid
CAS Number:
[114719-57-2]
Formula:
C18H11ClN2O4
Application Notes:
A novel marine natural product isolated from Thorectandra sp1. A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 µM) and is less selective for Cdk6/D1 (IC50 = 3.4 µM). Displays antiangiogenic acitivity2. Displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS3.
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