BTB-1, CAS [[86030-08-2]]

Product Overview

• Article Name: BTB-1, CAS [[86030-08-2]]
• Biozol Catalog Number: FBM-10-1543
• Supplier Catalog Number: 10-1543
• Alternative Catalog Number: FBM-10-1543-10MG, FBM-10-1543-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)-benzene. Alternate Names: NSC 156750

Product Description

Mitotic kinesin Kif18A inhibitor

Product Properties

• Molecular Weight: 297.71
• Purity: 98% by HPLC NMR (Conforms)
• Form: White or off-white solid
• CAS Number: [86030-08-2]
• Formula: C12H8ClNO4S

Application Notes

• Application Notes: A selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 M.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5