UCF-101, CAS [[313649-08-0]]

Product Overview

• Article Name: UCF-101, CAS [[313649-08-0]]
• Biozol Catalog Number: FBM-10-1544
• Supplier Catalog Number: 10-1544
• Alternative Catalog Number: FBM-10-1544-5MG, FBM-10-1544-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: Dihydro-5[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione

Product Description

Omi/HtrA2 protease inhibitor

Product Properties

• Molecular Weight: 495.51
• Purity: 98% by TLC
• Form: Orange solid
• CAS Number: [313649-08-0]
• Formula: C27H17N3O5S

Application Notes

• Application Notes: UCF-101 is a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 µM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 200 µM).1 Mitigates streptozotocin-induced cardiomyocyte dysfunction.2 Protects against cerebral oxidative injury and cognitive impairment in a rat model.3 Cell permeable.