Chemical Name: N-Benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine. Alternate Names: CID49830260
p97 AAA ATPase inhibitor
Molecular Weight:
372.46
Purity:
98% by HPLC NMR (conforms)
Form:
Pale yellow solid
CAS Number:
[1346528-06-0]
Formula:
C23H24N4O
Application Notes:
Potent and selective p97 AAA ATPase inhibitor, IC50=100 nM. Inhibits degradation of a p97-dependent but not p97-independent proteasome substrate in a dual-reporter cell line1. It impairs the endoplasmic reticulum-associated degradation (ERAD) pathway.1 ML241 and related inhibitors (DBeQ for example) have differential responses to p97 mutants as well as the presence of cofactors suggesting the possibility of context-dependent p97 inhibitors.2,3
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