Chemical Name: Dinaphthol[2,3-b:2,3-d]thiophene-5,7,12,13-tetraone
Autophagy inducer
Molecular Weight:
344.34
Purity:
98% by TLC, NMR (Conforms)
Form:
Orange solid
CAS Number:
[22200-69-7]
Formula:
C20H8O4S
Application Notes:
A new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin as determined using an immunoaffinity approach.1
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