Dienamide A2, CAS [[24738-51-0]]

Product Overview

• Article Name: Dienamide A2, CAS [[24738-51-0]]
• Biozol Catalog Number: FBM-10-1621
• Supplier Catalog Number: 10-1621
• Alternative Catalog Number: FBM-10-1621-5MG, FBM-10-1621-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2E,4E)-N-Isobutyldodeca-2,4-dienamide

Product Description

Novel cannabinoid CB2 agonist, antiinflammatory

Product Properties

• Molecular Weight: 251.41
• Purity: 98% by TLC NMR conforms
• Form: White solid
• CAS Number: [24738-51-0]
• Formula: C16H29NO

Application Notes

• Application Notes: Analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFalpha mRNA expression in human monocytes/macrophages via the CB2 receptor.1 Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively)2. It elevates intracellular Ca2+ levels in CB2-positive but not in CB2-negative cells and this effect was blocked by SR144528.2 It significantly inhibits LPS-induced TNFalpha and IL-1beta expression in a CB2-independent manner.2