Chemical Name: Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]
HDAC inhibitor
Molecular Weight:
623.78
Purity:
>98%
Form:
White solid
CAS Number:
[183506-66-3]
Formula:
C34H49N5O6
Application Notes:
Apicidin is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDACs).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression causing cell cycle arrest in the G1 phase.2 Apicidin dramatically decreases HIF-1alpha protein levels and transcriptional activity in human and mouse tumor cell lines.3
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