Myriocin (ISP-1), CAS [[35891-70-4]]

Product Overview

• Article Name: Myriocin (ISP-1), CAS [[35891-70-4]]
• Biozol Catalog Number: FBM-10-2088
• Supplier Catalog Number: 10-2088
• Alternative Catalog Number: FBM-10-2088-5MG,FBM-10-2088-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: ISP-1

Product Description

Blocks sphingolipid biosynthesis

Product Properties

• Molecular Weight: 401.54
• Purity: >98%
• Form: Off-white solid
• CAS Number: [35891-70-4]
• Formula: C21H39NO6

Application Notes

• Application Notes: Myriocin is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.3