Chemical Name: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid. Alternate Names: ISP-1
Blocks sphingolipid biosynthesis
Molecular Weight:
401.54
Purity:
>98%
Form:
Off-white solid
CAS Number:
[35891-70-4]
Formula:
C21H39NO6
Application Notes:
Myriocin is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.3
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