Chemical Name: N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride
PKA inhibitor
Molecular Weight:
519.28
Purity:
98% by TLC NMR (Conforms)
Form:
Off-white solid
CAS Number:
[127243-85-0]
Formula:
C20H20BrN3O2S2HCl
Application Notes:
H-89 is a commonly used inhibitor of protein kinase A (PKA IC50 = 140 nM). Inhibits a variety of other kinases including S6K1 (IC50 = 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBalpha (2.6 µM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 µM).1,2
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