VX-702, CAS [[745833-23-2]]

Product Overview

• Article Name: VX-702, CAS [[745833-23-2]]
• Biozol Catalog Number: FBM-10-2181
• Supplier Catalog Number: 10-2181
• Alternative Catalog Number: FBM-10-2181-10MG, FBM-10-2181-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide

Product Description

p38alpha MAP kinase inhibitor

Product Properties

• Molecular Weight: 404.32
• Purity: 98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [745833-23-2]
• Formula: C19H12F4N4O2

Application Notes

• Application Notes: A potent and selective inhibitor of p38 MAP kinases, p38 MAPK and p38 (KD = 3.7 and 17 nM respectively).1 Inhibits IL-6, IL-1 and TNF production in LPS-primed blood.1 Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 M.2 Provides only modest clinical efficacy in rheumatoid arthritis.3,4 Delays platelet lesions and leads to better maintenance of stored platelets.5