Chemical Name: Cis-Diaminodichloroplatinum. Alternate Names: CDDP, cis-Diamineplatinum(II) dichloride
Anticancer agent
Molecular Weight:
300.05
Purity:
98% by HPLC, Elemental Analysis (Conforms)
Form:
Yellow solid
CAS Number:
[15663-27-1]
Formula:
Cl2H4N2Pt
Application Notes:
Induces intra- and interstrand DNA adducts which poison topoisomerase I.1 Synergizes with topoisomerase I inhibitors such as topotecan.1 Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma cells.2 Inhibits expression of X-linked inhibitor of apoptosis protein (XIAP) in human LNCaP cells.3 Numerous mechanisms inhibit propagation of cisplatin-induced DNA damage to signal apoptosis resulting in resistance.4 Clinically useful anticancer agent.
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