Topotecan HCl, CAS [[119413-54-6]]

Product Overview

• Article Name: Topotecan HCl, CAS [[119413-54-6]]
• Biozol Catalog Number: FBM-10-2479
• Supplier Catalog Number: 10-2479
• Alternative Catalog Number: FBM-10-2479-10MG, FBM-10-2479-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 10-[(Dimethylamino)methyl]-4S-ethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride. Alternate Names: NSC 609669, SKF-104864A

Product Description

DNA topoisomerase I inhibitor

Product Properties

• Molecular Weight: 457.91
• Purity: >98% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [119413-54-6]
• Formula: C23H23N3O5 HCl

Application Notes

• Application Notes: Topotecan HCl is a water-soluble and orally active analog of camptothecin, a DNA topoisomerase I inhibitor.1 Inhibits topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells, IC50s = 13 and 2 nM respectively.2 Downregulates B-Myb and MycN expression in neuroblastoma cells.3 A clinically useful anticancer agent.