Chemical Name: N-[(3S)-7-Amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide. Alternate Names: Tosyl-L-lysyl-chloromethane hydrochloride
Serine protease inhibitor
Molecular Weight:
369.30
Purity:
>98% by HPLC NMR (Conforms)
Form:
Off-white solid
CAS Number:
[4272-74-6]
Formula:
C14H21ClN2O3S HCl
Application Notes:
TLCK is an irreversible inhibitor of trypsin and trypsin-like serine proteases.1 Has been used to inhibit proteases in protein purification protocols.2 Blocks LPS- or cytokine-induced NF-kappaB activation.3 Inhibits caspase processing, blocks apoptosis. Inhibits in vitro immortalization of primary human keratinocytes by HPV-18DNA.4 Active in vitro and in vivo.
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