Stattic, CAS [[19983-44-9]]

Product Overview

• Article Name: Stattic, CAS [[19983-44-9]]
• Biozol Catalog Number: FBM-10-2524
• Supplier Catalog Number: 10-2524
• Alternative Catalog Number: FBM-10-2524-10MG, FBM-10-2524-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide

Product Description

STAT3 inhibitor

Product Properties

• Molecular Weight: 211.20
• Purity: 98% by TLC, NMr (Conforms)
• Form: Light yellow solid
• CAS Number: [19983-44-9]
• Formula: C8H5NO4S

Application Notes

• Application Notes: STAT3 inhibitor. Inhibits binding of tyrosine-phosphorylated peptides to STAT3 SH2 domain and inhibiting STAT3 activation, dimerization and nuclear translocation1. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines. Alkyates four cysteine residues on STAT32. Exhibits potent antitumor activity3. Protects against angiotensin II-induced vascular dysfunction and hypertension4. An extremely useful tool to probe involvement of STAT3 in cellular signaling.