Chemical Name: An alkaloid from Amaryllidaceae. Alternate Names: Galanthidine, Amarylline, Narcissine
Protein synthesis inhibitor/SCAP degrader
Molecular Weight:
323.77
Purity:
98% by TLC NMR (Conforms)
Form:
White or off-white solid
CAS Number:
[2188-68-3]
Formula:
C16H17NO4 HCl
Application Notes:
Arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 µM4. A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5
* VAT and and shipping costs not included. Errors and price changes excepted
