A potent, covalent inhibitor of the NLRP3 inflammasome with anti-inflammatory activity in various mouse models.1 Inhibits vascular inflammation in vivo.2 Inhibits aberrant AKT activation in human breast cancer cells with hyperactivated PI3K/AKT signaling.3 Inhibits migration, invasion and adhesion of melanoma cells.4 Induces apoptosis in osteosarcoma cells by multiple pathways.5
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