Monastrol, CAS [[254753-54-3]]

Product Overview

• Article Name: Monastrol, CAS [[254753-54-3]]
• Biozol Catalog Number: FBM-10-2629
• Supplier Catalog Number: 10-2629
• Alternative Catalog Number: FBM-10-2629-5MG, FBM-10-2629-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester

Product Description

Kinesin Eg5 and mitosis inhibitor

Product Properties

• Molecular Weight: 292.35
• Purity: 98% by TLC NMR (Conforms)
• Form: Beige solid
• CAS Number: [254753-54-3]
• Formula: C14H16N2O3S

Application Notes

• Application Notes: Potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1 Does not affect other motor proteins or tubulin. Specifically inhibits the mitotic molecular motor kinesin Eg5, a motor protein required for spindle formation (IC50 = 14 µM).2 Mimics the effect of amyloid beta on long term potentiation in a cellular model of learning and memory.3 Enhances regeneration of adult axons.4