Migalastat, CAS [[75172-81-5]]

Product Overview

• Article Name: Migalastat, CAS [[75172-81-5]]
• Biozol Catalog Number: FBM-10-2632
• Supplier Catalog Number: 10-2632
• Alternative Catalog Number: FBM-10-2632-1MG,FBM-10-2632-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: 1-deoxygalactonojirimycin, DDIG, AT1001, DGJ, GR181413

Product Description

Galactosidase inhibitor, pharmacological chaperone

Product Properties

• Molecular Weight: 199.63
• Purity: >98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [75172-81-5]
• Formula: C6H13NO4 HCl

Application Notes

• Application Notes: Migalastat is a potent, selective, and orally available inhibitor of alpha-galactosidase A (IC50= 40 nM).1 It binds to mutant misfolded alpha-GalA shifting the folding behavior toward functional active conformation (pharmacological chaperone activity) followed by trafficking to the lysosomes.2 Migalastat is active broadly across species from Drosophila3 to human4. Clinically useful agent for Fabry disease.5