Chemical Name: 2R-(Hydroxymethyl)-3R,4R,5R-piperidinetriol hydrochloride. Alternate Names: 1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride
Mannosidase inhibibitor
Molecular Weight:
199.63
Purity:
98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[73465-43-7]
Formula:
C6H13NO4 HCl
Application Notes:
Potent and selective inhibitor of alpha-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and Abeta1-42-induced ER stress dependent neuronal cell death and protects primary cultured mouse cortical neurons from Abeta1-42 toxicity.4 Increases titers (4 fold) in the production of lentivirus vectors with enhanced efficiency in targeting dendritic cells.5,6
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