Potent and selective inhibitor of alpha-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and Abeta1-42-induced ER stress dependent neuronal cell death and protects primary cultured mouse cortical neurons from Abeta1-42 toxicity.4 Increases titers (4 fold) in the production of lentivirus vectors with enhanced efficiency in targeting dendritic cells.5,6
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