Leelamine HCl, CAS [[16496-99-4]]

Product Overview

• Article Name: Leelamine HCl, CAS [[16496-99-4]]
• Biozol Catalog Number: FBM-10-2955
• Supplier Catalog Number: 10-2955
• Alternative Catalog Number: FBM-10-2955-10MG, FBM-10-2955-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride. Alternate Names: Lylamine HCl, (+)-Dehydroabietylamine HCl

Product Description

Intracellular cholesterol inhibitor

Product Properties

• Molecular Weight: 321.93
• Purity: 98% by TLC NMR (Conforms)
• Form: Off-white or beige solid
• CAS Number: [16496-99-4]
• Formula: C20H31N HCl

Application Notes

• Application Notes: A lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux.1 Induces apoptosis in breast cancer2, melanoma3 and prostate cancer cells4. A selective inducer of cytochrome P450 2B.5 Inhibits pyruvate dehydrogenase kinase (PDK), IC50=9.5 µM.6