Embelin, CAS [[550-24-3]]

Product Overview

• Article Name: Embelin, CAS [[550-24-3]]
• Biozol Catalog Number: FBM-10-2959
• Supplier Catalog Number: 10-2959
• Alternative Catalog Number: FBM-10-2959-10MG, FBM-10-2959-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione

Product Description

XIAP inhibitor, Apoptosis inducer

Product Properties

• Molecular Weight: 294.39
• Purity: 98% by HPLC, NMR (Conforms)
• Form: Dark orange solid
• CAS Number: [550-24-3]
• Formula: C17H26O4

Application Notes

• Application Notes: Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 µM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 µM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells3. Possesses anti-inflammatory and analgesic activity in vivo4. Cell-permeable.