PAC-1, CAS [[315183-21-2]]

Product Overview

• Article Name: PAC-1, CAS [[315183-21-2]]
• Biozol Catalog Number: FBM-10-2979
• Supplier Catalog Number: 10-2979
• Alternative Catalog Number: FBM-10-2979-5MG, FBM-10-2979-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]-methylene]hydrazide

Product Description

Procaspase activator

Product Properties

• Molecular Weight: 392.49
• Purity: 98% by HPLC, NMR (Conforms)
• Form: Off-white solid
• CAS Number: [315183-21-2]
• Formula: C23H28N4O2

Application Notes

• Application Notes: PAC-1 is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 µM.1 It is less potent at activating procaspase-7, EC50=4.5 µM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2 Sensitizes cancer cells to various chemotherapeutic agents.3