Chemical Name: 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester. Alternate Names: FR34235
Syk inhibitor and Ca channel blocker
Molecular Weight:
385.38
Purity:
98% by TLC, NMR (Conforms)
Form:
Yellow solid
CAS Number:
[75530-68-6]
Formula:
C19H19N3O6
Application Notes:
A novel DHP L-type Ca2+ channel blocker that also inhibits Syk.1 Blocks Abeta production, APPbeta secretion and reduces BACE-1 expression in CHO cells over-expressing Abeta in vitro. Enhances clearance of Abeta across the blood brain barrier in vivo. Reduces brain Abeta levels in a mouse tauopathy model.1 Clinically useful antihypertensive agent.2 Has been shown to prevent cognitive decline in some clinical trials.3 Produces a protective effect on glutamate neurotoxicity in retinal ganglion cells, an effect not shared by other L-type Ca2+ channel blockers such as nifedipine and diltiazem.4
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