Nelfinavir is a clinically useful anti-HIV agent acting via inhibition of HIV-1 protease (Ki=2 nM).1 It also displays efficacy in cancer, malaria, tuberculosis and SARS.2 Displays broad spectrum anticancer activity and induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo.3 Inhibits the growth of HER2-positive breast cancer cells via inhibition of HSP90 through a novel mechanism.4
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