Chemical Name: (E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one
p53 activator
Molecular Weight:
265.27
Purity:
98% by TLC NMR (Conforms)
Form:
Off-white solid
CAS Number:
[803647-40-7]
Formula:
C12H15N3O4
Application Notes:
p53 activator. Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein degradation via MDM2 and ubiquitin-proteasome pathway. Induces p73-dependent cell death in cancer cells without toxicity toward normal cells.1 Inhibition of p53-MDM2 interaction remains a viable strategy for cancer therapeutic development.2,3
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