TPPU, CAS [[1222780-33-7]]

Product Overview

• Article Name: TPPU, CAS [[1222780-33-7]]
• Biozol Catalog Number: FBM-10-3451
• Supplier Catalog Number: 10-3451
• Alternative Catalog Number: FBM-10-3451-5MG, FBM-10-3451-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[1-(1-Oxopropyl)-4-piperidinyl]-N-[4-trifluoromethoxy)phenyl]urea

Product Description

Soluble epoxide hydrolase inhibitor

Product Properties

• Molecular Weight: 359.35
• Purity: >98% by HPLC NMR (Conforms)
• Form: White or off-white solid
• CAS Number: [1222780-33-7]
• Formula: C16H20F3N3O3

Application Notes

• Application Notes: TPPU is a potent and selective inhibitor of both murine and human soluble epoxide hydrolase, IC50=2.8 and 3.7 nM respectively.1 It alleviated blood brain barrier damage and attenuated neuronal injury in a mouse intracerebral hemorrhage model2 and displays neuroprotective effects in ischemic injury3. It reduces neuroinflammation in a mouse model of Alzheimers disease.4 It improves insulin resistance and reduced hypertension in mouse models.5 Cell permeable and active in vivo.