Autophinib, CAS [[1644443-47-9]]

Product Overview

• Article Name: Autophinib, CAS [[1644443-47-9]]
• Biozol Catalog Number: FBM-10-3476
• Supplier Catalog Number: 10-3476
• Alternative Catalog Number: FBM-10-3476-5MG, FBM-10-3476-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine

Product Description

Autophagy inhibitor

Product Properties

• Molecular Weight: 346.73
• Purity: >98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1644443-47-9]
• Formula: C14H11ClN6O3

Application Notes

• Application Notes: Inhibits autophagy induced by starvation or rapamycin by inhibiting the lipid kinase VPS34 (IC50=19 nM).1 Increased autophagy and apoptosis were rescued by autophinib in Per1-overexpressing oral squamous cell carcinoma cells.2 Autophinib has quickly become an important biochemical tool for inhibition of autophagy in a variety of cellular contexts.3-5