Chemical Name: N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester
HDAC2 inhibitor
Molecular Weight:
278.35
Purity:
98% by TLC NMR (Conforms)
Form:
Off-white solid
CAS Number:
[1477949-42-0]
Formula:
C15H22N2O3
Application Notes:
A highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1 Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2 Potential therapeutic agent for breast cancer.3 Attenuates A fragment (A25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4 Ameliorates Alzheimers disease-like pathology in mouse models.4
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