TG-100572 HCl, CAS [[867331-64-4]]

Product Overview

• Article Name: TG-100572 HCl, CAS [[867331-64-4]]
• Biozol Catalog Number: FBM-10-3778
• Supplier Catalog Number: 10-3778
• Alternative Catalog Number: FBM-10-3778-1MG, FBM-10-3778-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-Chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)benzo[e][1,2,4]triazin-7-yl)phenol hydrochloride

Product Description

Multi-kinase inhibitor

Product Properties

• Molecular Weight: 512.44
• Purity: >98% by HPLC NMR (conforms)
• Form: Pink solid
• CAS Number: [867331-64-4]
• Formula: C26H26ClN5O2 HCl

Application Notes

• Application Notes: TG-100572 is a multi-targeted kinase inhibitor that inhibits selected receptor kinases and Src kinases. IC50s = 2, 7, 2, 16, 13 VEGFR1, VEGFR2, FGFR1, FGFR2 PDGFRbeta and 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for Fgr, Fyn, Hck, Lck, Lyn, Src and Yes respectively.1 It suppresses choroidal neovascularization and retinal edema1. Blocks angiogenesis caused by HSV infection in the mouse eye.2 A prodrug strategy has been employed for topically applied AMD treatment.3