Chemical Name: 2-[2,6-Dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acid. Alternate Names: GFT505
PPARalpha/delta agonist
Molecular Weight:
384.49
Purity:
98% by HPLC NMr (Conforms)
Form:
Pale yellow solid
CAS Number:
[923978-27-2]
Formula:
C22H24O4S
Application Notes:
Elafibranor is a dual PPARalpha/delta agonist (EC50 PPARalpha = 10-20 nM, PPARdelta = 100-150 nM).1 It was able to decrease plasma triglycerides levels1, increase HDL cholesterol levels in human studies1, and improve hepatic and peripheral insulin sensitivity2. Elafibranors antidiabetic effects in db/db were without the adverse cardiac effects seen in PPARgamma agonism.3 Elafibranor has also been shown to have therapeutic promise in the treatment of nonalcoholic steatohepatitis (NASH).4-6
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