IMT1B, CAS [[2304621-06-3]]

Product Overview

• Article Name: IMT1B, CAS [[2304621-06-3]]
• Biozol Catalog Number: FBM-10-3919
• Supplier Catalog Number: 10-3919
• Alternative Catalog Number: FBM-10-3919-5MG,FBM-10-3919-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: LDC203974

Product Description

Mitochondrial DNA transcription inhibitor/RNA Polymerase inhibitor

Product Properties

• Molecular Weight: 473.88
• Purity: >98% by HPLC NMR Conforms
• Form: White to off-white solid
• CAS Number: [2304621-06-3]
• Formula: C24H21ClFNO6

Application Notes

• Application Notes: IMT1B (2304621-06-3) is a specific inhibitor of mitochondrial DNA (mtDNA) transcription. It targets an allosteric binding site on human mitochondrial RNA polymerase leading to impairment of biogenesis of the oxidative phosphorylation (OXPHOS) system.1 IMT1B displayed efficacy in mice containing human A2780 or DLD-1 cancer cell xenografts. IC50 = 138 nM A2780 cancer cells.2