EN450, CAS [[793719-01-4]]

Product Overview

• Article Name: EN450, CAS [[793719-01-4]]
• Biozol Catalog Number: FBM-10-3936
• Supplier Catalog Number: 10-3936
• Alternative Catalog Number: FBM-10-3936-5MG, FBM-10-3936-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-(2-Chloro-5-(N,N-dimethylsulfamoyl)phenyl)acrylamide. Alternate Names: N-[2-Chloro-5-(dimethylsulfamoyl)phenyl]prop-2-enamide

Product Description

NFkB1 molecular glue

Product Properties

• Molecular Weight: 288.75
• Purity: >98% by HPLC , NMR (Conforms)
• Form: White to off-white solid
• CAS Number: [793719-01-4]
• Formula: C11H13ClN2O3S

Application Notes

• Application Notes: EN450 is a molecular glue that covalently interacts with a cysteine residue on the E2 ubiquitin ligase UBE2D. It displayed anti-proliferative effects in HAP1 leukemia cells. EN450s antiproliferative effects were elicited via proteasome-dependent degradation of nuclear factor kappa B subunit 1(NFkB1).1