Pridopidine, CAS [[346688-38-8]]

Product Overview

• Article Name: Pridopidine, CAS [[346688-38-8]]
• Biozol Catalog Number: FBM-10-4003
• Supplier Catalog Number: 10-4003
• Alternative Catalog Number: FBM-10-4003-5MG, FBM-10-4003-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine. Alternate Names: ACR16

Product Description

Sigma-1 ligand/neuroprotective/restorative

Product Properties

• Molecular Weight: 281.41
• Purity: 98% by TLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [346688-38-8]
• Formula: C15H23NO2S

Application Notes

• Application Notes: Pridopidine is being studied as a potential treatment for Huntingtons disease, Parkinsons disease, and schizophrenia based on its locomotor stabilizing and antipsychotic-like effects.1,2 It was, unusually, able to reverse both hypo- and hyperdopaminergia depending on local dopamine concentrations without inducing catalepsy. This was originally attributed to functional dopamine D2 antagonism with fast on/off kinetics (''dopamine stabilizer).3 More recent studies have attributed pridopidines effects to its being a more potent sigma-1 ligand than a D2 ligand.4,5 Displays neuroprotective/restorative effects6,7 and ameliorates central features of amyotrophic lateral sclerosis pathology8 in a sigma-1-mediated manner