GSK2879552, CAS [[1401966-69-5]]

Product Overview

• Article Name: GSK2879552, CAS [[1401966-69-5]]
• Biozol Catalog Number: FBM-10-4020
• Supplier Catalog Number: 10-4020
• Alternative Catalog Number: FBM-10-4020-5MG, FBM-10-4020-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-[[4-[[[(1R,2S)-2-Phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]benzoic acid dihydrochloride

Product Description

LSD1 inhibitor

Product Properties

• Molecular Weight: 437.40
• Purity: 98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1401966-69-5]
• Formula: C23H28N2O2 2HCl

Application Notes

• Application Notes: GSK289552 is potent, selective, and irreversible inhibitor of Lysine Demethylase 1 (LSD1) via covalent modification of the LSD1 cofactor FAD (Ki = 1.7 µM). It is selective for LSD1 over the closely related LSD2, MAO-A, MAO-B, and the FAD dependent enzymes D-amino acid oxidase and glutathione reductase. Tested against a panel of 165 cancer cell lines, GSK2879552 inhibited the proliferation of 9 small cell lung carcinoma lines and 20 AML cell lines.