Chemical Name: 1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4-dione. Alternate Names: FEN1-IN-1
FEN1 inhibitor
Molecular Weight:
332.33
Purity:
98% by TLC , NMR (Conforms)
Form:
Off-white solid
CAS Number:
[824983-91-7]
Formula:
C15H12N2O5S
Application Notes:
Potent (IC50 = 11 nM) inhibitor of flap endonuclease 1 (FEN1).1 It showed similar potency in inhibiting exonuclease 1 (EXO1).2 Induces a DNA damage response and ultimately cell death. FEN1 inhibitors have therapeutic potential for the treatment of cancers that are defective for homologous repair and other DNA repair and DNA damage checkpoint pathways.4
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