Chemical Name: 3,5-Dimethyl-N-[4-(phenylmethyl)phenyl]-4-isoxazolesulfonamide
Protein phosphatase 5 inhibitor
Molecular Weight:
342.41
Purity:
>98% by HPLC NMR (Conforms)
Form:
Beige solid
CAS Number:
[1022417-69-1]
Formula:
C18H18N2O3S
Application Notes:
P053 is a selective inhibitor of protein phosphatase 5 (PP5) - IC50 = 706 nM.1 PP5 regulates signaling cascades that are responsible for tumor initiation, progression, and metastasis and is thus an interesting anticancer target. P053 induced apoptosis in 786-O renal carcinoma cells. Inhibition of PP5 by P053 prevents deactivation of the death effector protein FADD and activates the extrinsic apoptosis pathway complex II.
* VAT and and shipping costs not included. Errors and price changes excepted
